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Design and Evaluation of Ambiphilic Aryl Thiol–Iminium-Based Molecules for Organocatalyzed Thioacyl Aminolysis

[Image: see text] Progress toward the design and synthesis of ambiphilic aryl thiol–iminium-based small molecules for organocatalyzed thioacyl aminolysis is reported. Here we describe the synthesis of a novel tetrahydroisoquinoline-derived scaffold, bearing both thiol and iminium functionalities, ca...

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Detalles Bibliográficos
Autores principales: Digal, Lori D., Kirkeby, Emily K., Austin, Maxwell J., Roberts, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018527/
https://www.ncbi.nlm.nih.gov/pubmed/36936301
http://dx.doi.org/10.1021/acsomega.2c07586