Quantifying factors that affect polygenic risk score performance across diverse ancestries and age groups for body mass index

Polygenic risk scores (PRS) have led to enthusiasm for precision medicine. However, it is well documented that PRS do not generalize across groups differing in ancestry or sample characteristics e.g., age. Quantifying performance of PRS across different groups of study participants, using genome-wid...

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Detalles Bibliográficos
Autores principales: Hui, Daniel, Xiao, Brenda, Dikilitas, Ozan, Freimuth, Robert R., Irvin, Marguerite R., Jarvik, Gail P., Kottyan, Leah, Kullo, Iftikhar, Limdi, Nita A., Liu, Cong, Luo, Yuan, Namjou, Bahram, Puckelwartz, Megan J., Schaid, Daniel, Tiwari, Hemant, Wei, Wei-Qi, Verma, Shefali, Kim, Dokyoon, Ritchie, Marylyn D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018532/
https://www.ncbi.nlm.nih.gov/pubmed/36540998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018532/
https://www.ncbi.nlm.nih.gov/pubmed/36540998

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