Cargando…

Early DNase-I therapy delays secondary brain damage after traumatic brain injury in adult mice

Traumatic brain injury (TBI) causes the release of danger-associated molecular patterns (DAMP) from damaged or dead cells, which contribute to secondary brain damage after TBI. Cell-free DNA (cfDNA) is a DAMP known to cause disruption of the blood–brain barrier (BBB), promote procoagulant processes,...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krämer, Tobias J., Pickart, Florian, Pöttker, Bruno, Gölz, Christina, Neulen, Axel, Pantel, Tobias, Goetz, Hermann, Ritter, Katharina, Schäfer, Michael K. E., Thal, Serge C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018640/ https://www.ncbi.nlm.nih.gov/pubmed/36928073 http://dx.doi.org/10.1038/s41598-023-30421-5

Ejemplares similares

Ribonuclease-1 treatment after traumatic brain injury preserves blood–brain barrier integrity and delays secondary brain damage in mice
por: Krämer, Tobias J., et al.
Publicado: (2022)

Large Vessel Vasospasm Is Not Associated with Cerebral Cortical Hypoperfusion in a Murine Model of Subarachnoid Hemorrhage
por: Neulen, Axel, et al.
Publicado: (2018)

Multifaceted Mechanisms of WY-14643 to Stabilize the Blood-Brain Barrier in a Model of Traumatic Brain Injury
por: Neuhaus, Winfried, et al.
Publicado: (2017)

A Volumetric Method for Quantification of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage
por: Neulen, Axel, et al.
Publicado: (2018)

Posttraumatic midazolam administration does not influence brain damage after experimental traumatic brain injury
por: Sebastiani, Anne, et al.
Publicado: (2022)

Sequestosome 1 Deficiency Delays, but Does Not Prevent Brain Damage Formation Following Acute Brain Injury in Adult Mice
por: Sebastiani, Anne, et al.
Publicado: (2017)

Neutrophils mediate early cerebral cortical hypoperfusion in a murine model of subarachnoid haemorrhage
por: Neulen, Axel, et al.
Publicado: (2019)

Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury
por: Krämer, Tobias J., et al.
Publicado: (2019)

A segmentation-based volumetric approach to localize and quantify cerebral vasospasm based on tomographic imaging data
por: Neulen, Axel, et al.
Publicado: (2017)

Correction to: Depletion of regulatory T cells increases T cell brain infiltration, reactive astrogliosis, and interferon-γ gene expression in acute experimental traumatic brain injury
por: Krämer, Tobias J., et al.
Publicado: (2019)

Correlation of cardiac function and cerebral perfusion in a murine model of subarachnoid hemorrhage
por: Neulen, Axel, et al.
Publicado: (2021)

AT 1 inhibition mediated neuroprotection after experimental traumatic brain injury is dependent on neutrophils in male mice
por: Timaru-Kast, Ralph, et al.
Publicado: (2023)

The Contractile Apparatus Is Essential for the Integrity of the Blood-Brain Barrier After Experimental Subarachnoid Hemorrhage
por: Luh, Clara, et al.
Publicado: (2018)

AT2 activation does not influence brain damage in the early phase after experimental traumatic brain injury in male mice
por: Timaru-Kast, Ralph, et al.
Publicado: (2022)

Plasminogen activator inhibitor‐1 augments damage by impairing fibrinolysis after traumatic brain injury
por: Griemert, Eva‐Verena, et al.
Publicado: (2019)

Comparison of Unruptured Intracranial Aneurysm Treatment Score and PHASES Score in Subarachnoid Hemorrhage Patients With Multiple Intracranial Aneurysms
por: Neulen, Axel, et al.
Publicado: (2021)

Influence of Age on Brain Edema Formation, Secondary Brain Damage and Inflammatory Response after Brain Trauma in Mice
por: Timaru-Kast, Ralph, et al.
Publicado: (2012)

Single Administration of Tripeptide α-MSH(11–13) Attenuates Brain Damage by Reduced Inflammation and Apoptosis after Experimental Traumatic Brain Injury in Mice
por: Schaible, Eva-Verena, et al.
Publicado: (2013)

Traumatic brain injury results in rapid pericyte loss followed by reactive pericytosis in the cerebral cortex
por: Zehendner, Christoph M., et al.
Publicado: (2015)

Influence of a Brief Episode of Anesthesia during the Induction of Experimental Brain Trauma on Secondary Brain Damage and Inflammation
por: Luh, Clara, et al.
Publicado: (2011)

Pharmacologic Inhibition of ADAM10 Attenuates Brain Tissue Loss, Axonal Injury and Pro-inflammatory Gene Expression Following Traumatic Brain Injury in Mice
por: Appel, Dominik, et al.
Publicado: (2021)

Continuous Intraarterial Nimodipine Infusion for the Treatment of Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage: A Retrospective, Single-Center Cohort Trial
por: Kramer, Andreas, et al.
Publicado: (2022)

Volatile Anesthetics Influence Blood-Brain Barrier Integrity by Modulation of Tight Junction Protein Expression in Traumatic Brain Injury
por: Thal, Serge C., et al.
Publicado: (2012)

Angiotensin II Receptor 1 Blockage Limits Brain Damage and Improves Functional Outcome After Brain Injury in Aged Animals Despite Age-Dependent Reduction in AT1 Expression
por: Timaru-Kast, Ralph, et al.
Publicado: (2019)

Early Reciprocal Effects in a Murine Model of Traumatic Brain Injury and Femoral Fracture
por: Ritter, Katharina, et al.
Publicado: (2021)

Immediate, but Not Delayed, Microsurgical Skull Reconstruction Exacerbates Brain Damage in Experimental Traumatic Brain Injury Model
por: Glover, Loren E., et al.
Publicado: (2012)

Automated Grading of Cerebral Vasospasm to Standardize Computed Tomography Angiography Examinations After Subarachnoid Hemorrhage
por: Neulen, Axel, et al.
Publicado: (2020)

Impact of pre-hospital handling and initial time to cranial computed tomography on outcome in aneurysmal subarachnoid hemorrhage patients with out-of-hospital sudden cardiac arrest—a retrospective bi-centric study
por: Pantel, Tobias, et al.
Publicado: (2023)

Delayed and progressive damages to juvenile mice after moderate traumatic brain injury
por: Zhao, Shu, et al.
Publicado: (2018)

Xenon improves long-term cognitive function, reduces neuronal loss and chronic neuroinflammation, and improves survival after traumatic brain injury in mice
por: Campos-Pires, Rita, et al.
Publicado: (2019)

Delayed unilateral traumatic brain swelling in a child
por: Paiva, Wellingson S., et al.
Publicado: (2014)

Hyperemia Causing Delayed Recovery in Traumatic Brain Injury
por: Nair, Shalini, et al.
Publicado: (2017)

Most brain disease-associated and eQTL haplotypes are not located within transcription factor DNase-seq footprints in brain
por: Handel, Adam E., et al.
Publicado: (2017)

Delayed and disorganised brain activation detected with magnetoencephalography after mild traumatic brain injury
por: da Costa, Leodante, et al.
Publicado: (2015)

PAI-1 but Not PAI-2 Gene Deficiency Attenuates Ischemic Brain Injury After Experimental Stroke
por: Griemert, Eva-Verena, et al.
Publicado: (2018)

DNase I hypersensitivity analysis of the mouse brain and retina identifies region-specific regulatory elements
por: Wilken, Matthew S, et al.
Publicado: (2015)

Traumatic Brain Injury and Delayed Sequelae: A Review - Traumatic Brain Injury and Mild Traumatic Brain Injury (Concussion) are Precursors to Later-Onset Brain Disorders, Including Early-Onset Dementia
por: Kiraly, Michael A., et al.
Publicado: (2007)

Mild traumatic brain injury and delayed alteration of memory processing
por: Foster, Philip P.
Publicado: (2015)

Delayed Sequelae Related to Mild Traumatic Brain Injury in Children
por: Chendrasekhar, Akella, et al.
Publicado: (2020)

Steroids for delayed cerebral edema after traumatic brain injury
por: Prasad, G. Lakshmi
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_328dm31achp1pfm8olh5v4casq