Cargando…
Strategy toward Kinase-Selective Drug Discovery
[Image: see text] Kinase drug selectivity is the ground challenge in cancer research. Due to the structurally similar kinase drug pockets, off-target inhibitor toxicity has been a major cause for clinical trial failures. The pockets are similar but not identical. Here, we describe a transformation i...
| Autores principales: | , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2023
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018734/ https://www.ncbi.nlm.nih.gov/pubmed/36815703 http://dx.doi.org/10.1021/acs.jctc.2c01171 |