Decrease in naturally occurring antibodies against epitopes of Alzheimer’s disease (AD) risk gene products is associated with cognitive decline in AD

BACKGROUND: Naturally occurring antibodies (NAbs) are germline-encoded immunoglobulins that can bind to and clear out self-neo-epitopes as well as apoptotic and necrotic cells. However, NAbs pathological relevance in Alzheimer’s disease (AD) is not well-understood. METHODS: Twenty-eight candidate pr...

Descripción completa

Detalles Bibliográficos
Autores principales: Gu, Dongmei, Wang, Luchun, Zhang, Nan, Wang, Huali, Yu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018846/
https://www.ncbi.nlm.nih.gov/pubmed/36922858
http://dx.doi.org/10.1186/s12974-023-02750-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018846/
https://www.ncbi.nlm.nih.gov/pubmed/36922858
http://dx.doi.org/10.1186/s12974-023-02750-9

Ejemplares similares