Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

BACKGROUND: Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid-β (Aβ) accumulation in the brain, although Aβ deposits mostly in the brain parenchyma in AD and in the cerebrovasculature in CAA. The presence of CAA can exacerbate clinical outcomes of AD pati...

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Detalles Bibliográficos
Autores principales: Xiong, Monica, Wang, Chao, Gratuze, Maud, Saadi, Fareeha, Bao, Xin, Bosch, Megan E., Lee, Choonghee, Jiang, Hong, Serrano, Javier Remolina, Gonzales, Ernesto R., Kipnis, Michal, Holtzman, David M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018855/
https://www.ncbi.nlm.nih.gov/pubmed/36922879
http://dx.doi.org/10.1186/s13024-023-00610-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018855/
https://www.ncbi.nlm.nih.gov/pubmed/36922879
http://dx.doi.org/10.1186/s13024-023-00610-x

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