Cargando…

Astrocytic APOE4 removal confers cerebrovascular protection despite increased cerebral amyloid angiopathy

BACKGROUND: Alzheimer Disease (AD) and cerebral amyloid angiopathy (CAA) are both characterized by amyloid-β (Aβ) accumulation in the brain, although Aβ deposits mostly in the brain parenchyma in AD and in the cerebrovasculature in CAA. The presence of CAA can exacerbate clinical outcomes of AD pati...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xiong, Monica, Wang, Chao, Gratuze, Maud, Saadi, Fareeha, Bao, Xin, Bosch, Megan E., Lee, Choonghee, Jiang, Hong, Serrano, Javier Remolina, Gonzales, Ernesto R., Kipnis, Michal, Holtzman, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10018855/ https://www.ncbi.nlm.nih.gov/pubmed/36922879 http://dx.doi.org/10.1186/s13024-023-00610-x

Ejemplares similares

Parenchymal border macrophages regulate tau pathology and tau-mediated neurodegeneration
por: Drieu, Antoine, et al.
Publicado: (2023)

Cerebrovascular Reactivity Across the Entire Brain in Cerebral Amyloid Angiopathy
por: Beaudin, Andrew E., et al.
Publicado: (2022)

Brain ApoA-I, ApoJ and ApoE Immunodetection in Cerebral Amyloid Angiopathy
por: Camacho, Jessica, et al.
Publicado: (2019)

The Cerebrovascular Basement Membrane: Role in the Clearance of β-amyloid and Cerebral Amyloid Angiopathy
por: Morris, Alan W. J., et al.
Publicado: (2014)

Cerebrovascular Risk Factors in Possible or Probable Cerebral Amyloid Angiopathy, Modifier or Bystander?
por: Wagner, Andrea, et al.
Publicado: (2021)

ApoA-I deficiency increases cortical amyloid deposition, cerebral amyloid angiopathy, cortical and hippocampal astrogliosis, and amyloid-associated astrocyte reactivity in APP/PS1 mice
por: Button, Emily B., et al.
Publicado: (2019)

Resorufin analogs preferentially bind cerebrovascular amyloid: potential use as imaging ligands for cerebral amyloid angiopathy
por: Han, Byung Hee, et al.
Publicado: (2011)

Al(18)F-NODA Benzothiazole Derivatives as Imaging Agents for Cerebrovascular Amyloid in Cerebral Amyloid Angiopathy
por: Song, Jia, et al.
Publicado: (2018)

Retinal amyloid angiopathy
por: Meira, Alex Tiburtino, et al.
Publicado: (2021)

Predicting Cerebral Amyloid Angiopathy-Related Intracerebral Hemorrhages and Other Cerebrovascular Disorders in Alzheimer’s Disease
por: Yamada, Masahito
Publicado: (2012)

Association of candidate genetic variants and circulating levels of ApoE/ApoJ with common neuroimaging features of cerebral amyloid angiopathy
por: Bonaterra-Pastra, Anna, et al.
Publicado: (2023)

Activated microglia mitigate Aβ-associated tau seeding and spreading
por: Gratuze, Maud, et al.
Publicado: (2021)

Cerebrovascular amyloid Angiopathy in bioengineered vessels is reduced by high-density lipoprotein particles enriched in Apolipoprotein E
por: Robert, Jerome, et al.
Publicado: (2020)

Gait in Cerebral Amyloid Angiopathy
por: Sharma, Breni, et al.
Publicado: (2022)

Cerebral amyloid angiopathy: an update
por: Schroeder, B. E., et al.
Publicado: (2023)

Cerebral amyloid angiopathy related inflammation: An under recognized but treatable complication of cerebral amyloid angiopathy
por: Berry-Noronha, Alexander, et al.
Publicado: (2023)

Tau and apolipoprotein E modulate cerebrovascular tight junction integrity independent of cerebral amyloid angiopathy in Alzheimer’s disease
por: Liu, Chia-Chen, et al.
Publicado: (2020)

Proteomics-based investigation of cerebrovascular molecular mechanisms in cerebral amyloid angiopathy by the FFPE-LMD-PCT-SWATH method
por: Handa, Takumi, et al.
Publicado: (2022)

Microglia drive APOE-dependent neurodegeneration in a tauopathy mouse model
por: Shi, Yang, et al.
Publicado: (2019)

The association between hypertensive angiopathy and cerebral amyloid angiopathy in primary intracerebral hemorrhage
por: Zhu, Yuyi, et al.
Publicado: (2023)

Superficial siderosis in cerebral amyloid angiopathy
por: Wani, Nisar Ahmad, et al.
Publicado: (2011)

Cerebral Amyloid Angiopathy: Emerging Concepts
por: Yamada, Masahito
Publicado: (2015)

Advances in cerebral amyloid angiopathy imaging
por: Chen, Szu-Ju, et al.
Publicado: (2019)

Understanding the Pathophysiology of Cerebral Amyloid Angiopathy
por: Gatti, Laura, et al.
Publicado: (2020)

Reversible Periventricular Hyperintensity Lesions in Cerebral Amyloid Angiopathy: A Case Mimicking Cerebral Amyloid Angiopathy-related Inflammation
por: Inoue, Yasuteru, et al.
Publicado: (2022)

The Amyloid-Tau-Neuroinflammation Axis in the Context of Cerebral Amyloid Angiopathy
por: Cisternas, Pablo, et al.
Publicado: (2019)

STAT3 inhibitor mitigates cerebral amyloid angiopathy and parenchymal amyloid plaques while improving cognitive functions and brain networks
por: Mehla, Jogender, et al.
Publicado: (2021)

Cerebral Amyloid Angiopathy: A Systematic Review
por: Biffi, Alessandro, et al.
Publicado: (2011)

Immunotherapy with ponezumab for probable cerebral amyloid angiopathy
por: Leurent, Claire, et al.
Publicado: (2019)

Cerebrospinal Fluid Biomarkers in Cerebral Amyloid Angiopathy
por: Banerjee, Gargi, et al.
Publicado: (2020)

The Role of Basement Membranes in Cerebral Amyloid Angiopathy
por: Howe, Matthew D., et al.
Publicado: (2020)

Effects of cerebral amyloid angiopathy on the brain vasculome
por: Deng, Wenjun, et al.
Publicado: (2022)

Cerebral Amyloid Angiopathy and the Risk of Hematoma Expansion
por: Seiffge, David J., et al.
Publicado: (2022)

Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy
por: Sembill, Jochen A, et al.
Publicado: (2023)

New insights into the role of TREM2 in Alzheimer’s disease
por: Gratuze, Maud, et al.
Publicado: (2018)

New Silent Cerebral Infarction in Patients with Acute Non-Cerebral Amyloid Angiopathy Intracerebral Hemorrhage as a Predictor of Recurrent Cerebrovascular Events
por: Wang, Yuan-Wei, et al.
Publicado: (2019)

Evidence of amyloid-β cerebral amyloid angiopathy transmission through neurosurgery
por: Jaunmuktane, Zane, et al.
Publicado: (2018)

Reduced vascular amyloid burden at microhemorrhage sites in cerebral amyloid angiopathy
por: van Veluw, Susanne J., et al.
Publicado: (2016)

Cerebral amyloid angiopathy in the aetiology and immunotherapy of Alzheimer disease
por: Weller, Roy O, et al.
Publicado: (2009)

Recurrent craniospinal subarachnoid hemorrhage in cerebral amyloid angiopathy
por: Alexander, Mathew, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_d17s5ps75mnk2q9it0r2f1virl