Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes

OBJECTIVE: Gestational diabetes (GDM) is increasing in prevalence with effects starting in-utero, leading to excessive fetal growth. It is the leading cause of many perinatal complications. The aim was to determine the rate of obstetric and neonatal complications in pregnant women with high fetal we...

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Autores principales: Jasim, Shaymaa Kadhim, Al-Momen, Hayder, Mahdi, Zina Ismaiel, Almomen, Rand
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Galenos Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019017/
https://www.ncbi.nlm.nih.gov/pubmed/36919478
http://dx.doi.org/10.4274/jtgga.galenos.2022.2021-10-6
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author Jasim, Shaymaa Kadhim
Al-Momen, Hayder
Mahdi, Zina Ismaiel
Almomen, Rand
author_facet Jasim, Shaymaa Kadhim
Al-Momen, Hayder
Mahdi, Zina Ismaiel
Almomen, Rand
author_sort Jasim, Shaymaa Kadhim
collection PubMed
description OBJECTIVE: Gestational diabetes (GDM) is increasing in prevalence with effects starting in-utero, leading to excessive fetal growth. It is the leading cause of many perinatal complications. The aim was to determine the rate of obstetric and neonatal complications in pregnant women with high fetal weight and a recent diagnosis of GDM during the third trimester, despite normal earlier glycemic control. MATERIAL AND METHODS: Prospective cohort study over four years involving pregnant women regularly visiting a single center who had normal glycemic index at 24-28 gestational weeks and ultrasonography (US) suggested high fetal weight during the third trimester. Oral glucose tolerance test was given, dividing the sample into the late GDM (LGDM) and the non-LGDM group RESULTS: Of 176 women, 24 (13.64%) had LGDM, and 152 (86.36%) had non-LGDM. After exclusions these groups’ sizes were (n=21) in LGDM and (n=132) in non-LGDM. Hemoglobin A1c level was significantly higher in LGDM than non-LGDM (5.9% versus 5.1%). However, obstetric and neonatal complications were largely comparable (p≥0.05) but higher in LGDM than non-LGDM women. Exceptions to this were birth weight (3219 g versus 3326 g), large for gestational age at delivery (85.72% versus 88.64%), and gestational age at delivery (37.9 versus 38.2 weeks) in the LGDM vs. non-LGDM groups, respectively. There was a significantly higher cesarean section (CS) rate (76.19% versus 51.52%; p<0.05) in the LGDM group. CONCLUSION: The rate of newly diagnosed LGDM in pregnant women with high fetal weight during the third trimester by US was 13.64%. They had comparable obstetric and neonatal complications with non-GDM women, except for the rate of CS that was significantly higher in LGDM women.
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spelling pubmed-100190172023-03-17 Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes Jasim, Shaymaa Kadhim Al-Momen, Hayder Mahdi, Zina Ismaiel Almomen, Rand J Turk Ger Gynecol Assoc Original Investigation OBJECTIVE: Gestational diabetes (GDM) is increasing in prevalence with effects starting in-utero, leading to excessive fetal growth. It is the leading cause of many perinatal complications. The aim was to determine the rate of obstetric and neonatal complications in pregnant women with high fetal weight and a recent diagnosis of GDM during the third trimester, despite normal earlier glycemic control. MATERIAL AND METHODS: Prospective cohort study over four years involving pregnant women regularly visiting a single center who had normal glycemic index at 24-28 gestational weeks and ultrasonography (US) suggested high fetal weight during the third trimester. Oral glucose tolerance test was given, dividing the sample into the late GDM (LGDM) and the non-LGDM group RESULTS: Of 176 women, 24 (13.64%) had LGDM, and 152 (86.36%) had non-LGDM. After exclusions these groups’ sizes were (n=21) in LGDM and (n=132) in non-LGDM. Hemoglobin A1c level was significantly higher in LGDM than non-LGDM (5.9% versus 5.1%). However, obstetric and neonatal complications were largely comparable (p≥0.05) but higher in LGDM than non-LGDM women. Exceptions to this were birth weight (3219 g versus 3326 g), large for gestational age at delivery (85.72% versus 88.64%), and gestational age at delivery (37.9 versus 38.2 weeks) in the LGDM vs. non-LGDM groups, respectively. There was a significantly higher cesarean section (CS) rate (76.19% versus 51.52%; p<0.05) in the LGDM group. CONCLUSION: The rate of newly diagnosed LGDM in pregnant women with high fetal weight during the third trimester by US was 13.64%. They had comparable obstetric and neonatal complications with non-GDM women, except for the rate of CS that was significantly higher in LGDM women. Galenos Publishing 2023-03 2023-03-15 /pmc/articles/PMC10019017/ /pubmed/36919478 http://dx.doi.org/10.4274/jtgga.galenos.2022.2021-10-6 Text en © Copyright 2023 by the Turkish-German Gynecological Education and Research Foundation https://creativecommons.org/licenses/by-nc-nd/4.0/Journal of the Turkish-German Gynecological Association published by Galenos Publishing House.
spellingShingle Original Investigation
Jasim, Shaymaa Kadhim
Al-Momen, Hayder
Mahdi, Zina Ismaiel
Almomen, Rand
Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
title Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
title_full Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
title_fullStr Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
title_full_unstemmed Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
title_short Obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
title_sort obstetric and neonatal complications in large for gestational age pregnancy with late gestational diabetes
topic Original Investigation
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019017/
https://www.ncbi.nlm.nih.gov/pubmed/36919478
http://dx.doi.org/10.4274/jtgga.galenos.2022.2021-10-6
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