Inducible Mega-Mediated Macrolide Resistance Confers Heteroresistance in Streptococcus pneumoniae

In Streptococcus pneumoniae (Spn), the 5.4 to 5.5 kb Macrolide Genetic Assembly (Mega) encodes an efflux pump (Mef[E]) and a ribosomal protection protein (Mel) conferring antibiotic resistance to commonly used macrolides in clinical isolates. We found the macrolide-inducible Mega operon provides het...

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Detalles Bibliográficos
Autores principales: Lohsen, Sarah, Stephens, David S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2023
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019249/
https://www.ncbi.nlm.nih.gov/pubmed/36847556
http://dx.doi.org/10.1128/aac.01319-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019249/
https://www.ncbi.nlm.nih.gov/pubmed/36847556
http://dx.doi.org/10.1128/aac.01319-22

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