Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population

BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a common and harmful disease that requires an effective tool to early screen high-risk individuals. Gansu has unique environments and customs, leading to the different prevalence and etiology of COPD from other regions. The association betw...

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Autores principales: Lin, Ao, Mao, Chun, Rao, Boqi, Zhao, Hongjun, Wang, Yunchao, Yang, Guokang, Lei, Haisheng, Xie, Chenli, Huang, Dongsheng, Deng, Yibin, Zhang, Xuhui, Wang, Xinhua, Lu, Jiachun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019355/
https://www.ncbi.nlm.nih.gov/pubmed/36935687
http://dx.doi.org/10.3389/fpubh.2023.1127566
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author Lin, Ao
Mao, Chun
Rao, Boqi
Zhao, Hongjun
Wang, Yunchao
Yang, Guokang
Lei, Haisheng
Xie, Chenli
Huang, Dongsheng
Deng, Yibin
Zhang, Xuhui
Wang, Xinhua
Lu, Jiachun
author_facet Lin, Ao
Mao, Chun
Rao, Boqi
Zhao, Hongjun
Wang, Yunchao
Yang, Guokang
Lei, Haisheng
Xie, Chenli
Huang, Dongsheng
Deng, Yibin
Zhang, Xuhui
Wang, Xinhua
Lu, Jiachun
author_sort Lin, Ao
collection PubMed
description BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a common and harmful disease that requires an effective tool to early screen high-risk individuals. Gansu has unique environments and customs, leading to the different prevalence and etiology of COPD from other regions. The association between altitude and COPD once attracted epidemiologists' attention. However, the prevalence in Gansu and the role of altitude are still unclarified. METHODS: In Gansu, a multistage stratified cluster sampling procedure was utilized to select a representative sample aged 40 years or older. The questionnaire and spirometry examination were implemented to collect participants' information. The diagnosis and assessment of COPD were identified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion, while post-bronchodilator FEV(1)/FVC < LLN was for sensitivity analysis. Furthermore, the effect of high altitude on COPD was evaluated by the logistic regression model after propensity score matching (PSM). Finally, the participants were randomly divided into training and validation sets. The training set was used to screen the relative factors and construct a nomogram which was further assessed by the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) in the two sets. RESULTS: There were 2,486 eligible participants in the final analysis, of which 1,584 lived in low altitudes and 902 lived in high altitudes. Based on the GOLD criterion, the crude and standardized prevalences in Gansu were 20.4% (18.7–22.0) and 19.7% (17.9–21.6). After PSM, the logistic regression model indicated that high altitude increased COPD risk [PSM OR: 1.516 (1.162–1.978)]. Altitude, age, sex, history of tuberculosis, coal as fuel, and smoking status were reserved for developing a nomogram that demonstrated excellent discrimination, calibration, and clinical benefit in the two sets. CONCLUSIONS: COPD has become a serious public health problem in Gansu. High altitude is a risk factor for COPD. The nomogram has satisfactory efficiency in screening high-risk individuals.
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spelling pubmed-100193552023-03-17 Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population Lin, Ao Mao, Chun Rao, Boqi Zhao, Hongjun Wang, Yunchao Yang, Guokang Lei, Haisheng Xie, Chenli Huang, Dongsheng Deng, Yibin Zhang, Xuhui Wang, Xinhua Lu, Jiachun Front Public Health Public Health BACKGROUND: Chronic Obstructive Pulmonary Disease (COPD) is a common and harmful disease that requires an effective tool to early screen high-risk individuals. Gansu has unique environments and customs, leading to the different prevalence and etiology of COPD from other regions. The association between altitude and COPD once attracted epidemiologists' attention. However, the prevalence in Gansu and the role of altitude are still unclarified. METHODS: In Gansu, a multistage stratified cluster sampling procedure was utilized to select a representative sample aged 40 years or older. The questionnaire and spirometry examination were implemented to collect participants' information. The diagnosis and assessment of COPD were identified by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criterion, while post-bronchodilator FEV(1)/FVC < LLN was for sensitivity analysis. Furthermore, the effect of high altitude on COPD was evaluated by the logistic regression model after propensity score matching (PSM). Finally, the participants were randomly divided into training and validation sets. The training set was used to screen the relative factors and construct a nomogram which was further assessed by the receiver operating characteristic (ROC) curve, calibration curve, and decision curve analysis (DCA) in the two sets. RESULTS: There were 2,486 eligible participants in the final analysis, of which 1,584 lived in low altitudes and 902 lived in high altitudes. Based on the GOLD criterion, the crude and standardized prevalences in Gansu were 20.4% (18.7–22.0) and 19.7% (17.9–21.6). After PSM, the logistic regression model indicated that high altitude increased COPD risk [PSM OR: 1.516 (1.162–1.978)]. Altitude, age, sex, history of tuberculosis, coal as fuel, and smoking status were reserved for developing a nomogram that demonstrated excellent discrimination, calibration, and clinical benefit in the two sets. CONCLUSIONS: COPD has become a serious public health problem in Gansu. High altitude is a risk factor for COPD. The nomogram has satisfactory efficiency in screening high-risk individuals. Frontiers Media S.A. 2023-03-02 /pmc/articles/PMC10019355/ /pubmed/36935687 http://dx.doi.org/10.3389/fpubh.2023.1127566 Text en Copyright © 2023 Lin, Mao, Rao, Zhao, Wang, Yang, Lei, Xie, Huang, Deng, Zhang, Wang and Lu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Lin, Ao
Mao, Chun
Rao, Boqi
Zhao, Hongjun
Wang, Yunchao
Yang, Guokang
Lei, Haisheng
Xie, Chenli
Huang, Dongsheng
Deng, Yibin
Zhang, Xuhui
Wang, Xinhua
Lu, Jiachun
Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population
title Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population
title_full Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population
title_fullStr Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population
title_full_unstemmed Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population
title_short Development and validation of nomogram including high altitude as a risk factor for COPD: A cross-sectional study based on Gansu population
title_sort development and validation of nomogram including high altitude as a risk factor for copd: a cross-sectional study based on gansu population
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019355/
https://www.ncbi.nlm.nih.gov/pubmed/36935687
http://dx.doi.org/10.3389/fpubh.2023.1127566
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