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RNAi in cell nuclei: potential for a new layer of biological regulation and a new strategy for therapeutic discovery
RNA interference is almost always associated with post-transcriptional silencing in the cytoplasm. MicroRNAs (miRNAs) and critical RNAi protein factors like argonaute (AGO) and trinucleotide repeat binding containing 6 protein (TNRC6), however, are also found in cell nuclei, suggesting that nuclear...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Cold Spring Harbor Laboratory Press
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019369/ https://www.ncbi.nlm.nih.gov/pubmed/36657971 http://dx.doi.org/10.1261/rna.079500.122 |