Identification of potential human pancreatic α-amylase inhibitors from natural products by molecular docking, MM/GBSA calculations, MD simulations, and ADMET analysis

Human pancreatic α-amylase (HPA), which works as a catalyst for carbohydrate hydrolysis, is one of the viable targets to control type 2 diabetes. The inhibition of α-amylase lowers blood glucose levels and helps to alleviate hyperglycemia complications. Herein, we systematically screened the potenti...

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Detalles Bibliográficos
Autores principales: Basnet, Santosh, Ghimire, Madhav Prasad, Lamichhane, Tika Ram, Adhikari, Rajendra, Adhikari, Achyut
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019617/
https://www.ncbi.nlm.nih.gov/pubmed/36928801
http://dx.doi.org/10.1371/journal.pone.0275765

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019617/
https://www.ncbi.nlm.nih.gov/pubmed/36928801
http://dx.doi.org/10.1371/journal.pone.0275765

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