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Identification of potential human pancreatic α-amylase inhibitors from natural products by molecular docking, MM/GBSA calculations, MD simulations, and ADMET analysis

Human pancreatic α-amylase (HPA), which works as a catalyst for carbohydrate hydrolysis, is one of the viable targets to control type 2 diabetes. The inhibition of α-amylase lowers blood glucose levels and helps to alleviate hyperglycemia complications. Herein, we systematically screened the potenti...

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Detalles Bibliográficos
Autores principales:	Basnet, Santosh, Ghimire, Madhav Prasad, Lamichhane, Tika Ram, Adhikari, Rajendra, Adhikari, Achyut
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019617/ https://www.ncbi.nlm.nih.gov/pubmed/36928801 http://dx.doi.org/10.1371/journal.pone.0275765

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