Using AlphaFold to predict the impact of single mutations on protein stability and function

AlphaFold changed the field of structural biology by achieving three-dimensional (3D) structure prediction from protein sequence at experimental quality. The astounding success even led to claims that the protein folding problem is “solved”. However, protein folding problem is more than just structu...

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Detalles Bibliográficos
Autores principales: Pak, Marina A., Markhieva, Karina A., Novikova, Mariia S., Petrov, Dmitry S., Vorobyev, Ilya S., Maksimova, Ekaterina S., Kondrashov, Fyodor A., Ivankov, Dmitry N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019719/
https://www.ncbi.nlm.nih.gov/pubmed/36928239
http://dx.doi.org/10.1371/journal.pone.0282689

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019719/
https://www.ncbi.nlm.nih.gov/pubmed/36928239
http://dx.doi.org/10.1371/journal.pone.0282689

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