From a genome-wide screen of RNAi molecules against SARS-CoV-2 to a validated broad-spectrum and potent prophylaxis

Expanding the arsenal of prophylactic approaches against SARS-CoV-2 is of utmost importance, specifically those strategies that are resistant to antigenic drift in Spike. Here, we conducted a screen of over 16,000 RNAi triggers against the SARS-CoV-2 genome, using a massively parallel assay to ident...

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Detalles Bibliográficos
Autores principales: Yogev, Ohad, Weissbrod, Omer, Battistoni, Giorgia, Bressan, Dario, Naamati, Adi, Falciatori, Ilaria, Berkyurek, Ahmet Can, Rasnic, Roni, Izuagbe, Rhys, Hosmillo, Myra, Ilan, Shaul, Grossman, Iris, McCormick, Lauren, Honeycutt, Christopher Cole, Johnston, Timothy, Gagne, Matthew, Douek, Daniel C, Goodfellow, Ian, Hannon, Gregory James, Erlich, Yaniv
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019795/
https://www.ncbi.nlm.nih.gov/pubmed/36928598
http://dx.doi.org/10.1038/s42003-023-04589-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10019795/
https://www.ncbi.nlm.nih.gov/pubmed/36928598
http://dx.doi.org/10.1038/s42003-023-04589-5

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