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Development of a new surgical technique to infuse kynurenic acid to optic nerves in chickens for studying loss of myelination

Prolonged infusion of a high dose of kynurenic acid (KYNA) reduces the myelin content in the rat spinal cord with preservation of the axonal integrity and without inducing an inflammatory response. We hypothesized that subdural infusion of a high concentration of KYNA can induce myelin loss in the o...

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Detalles Bibliográficos
Autores principales: Gurdita, Akshay, Kwiecien, Jacek M., Choh, Vivian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020079/
https://www.ncbi.nlm.nih.gov/pubmed/36938412
http://dx.doi.org/10.1016/j.heliyon.2023.e14361