Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332

PF-07321332 and PF-07304814, inhibitors against SARS-CoV-2 developed by Pfizer, exhibit broad-spectrum inhibitory activity against the main protease (M(pro)) from various coronaviruses. Structures of PF-07321332 or PF-07304814 in complex with M(pro)s of various coronaviruses reveal their inhibitory...

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Detalles Bibliográficos
Autores principales: Zhou, Yanru, Wang, Weiwei, Zeng, Pei, Feng, Jingwen, Li, Dongyang, Jing, Yue, Zhang, Jin, Yin, Xiushan, Li, Jian, Ye, Heyang, Wang, Qisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Inc. 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020134/
https://www.ncbi.nlm.nih.gov/pubmed/36965419
http://dx.doi.org/10.1016/j.bbrc.2023.03.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020134/
https://www.ncbi.nlm.nih.gov/pubmed/36965419
http://dx.doi.org/10.1016/j.bbrc.2023.03.043

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