Modulating the proliferative and cytotoxic properties of patient-derived TIL by a synthetic immune niche of immobilized CCL21 and ICAM1

A major challenge in developing an effective adoptive cancer immunotherapy is the ex-vivo generation of tumor-reactive cells in sufficient numbers and with enhanced cytotoxic potential. It was recently demonstrated that culturing of activated murine CD8+ T-cells on a “Synthetic Immune Niche” (SIN),...

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Detalles Bibliográficos
Autores principales: Yunger, Sharon, Geiger, Benjamin, Friedman, Nir, Besser, Michal J., Adutler-Lieber, Shimrit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020329/
https://www.ncbi.nlm.nih.gov/pubmed/36937426
http://dx.doi.org/10.3389/fonc.2023.1116328

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020329/
https://www.ncbi.nlm.nih.gov/pubmed/36937426
http://dx.doi.org/10.3389/fonc.2023.1116328

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