Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy

Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit clinical translation. We modify endogenous dyn...

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Detalles Bibliográficos
Autores principales: Lohman, Rink-Jan, Reddy Tupally, Karnaker, Kandale, Ajit, Cabot, Peter J., Parekh, Harendra S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020352/
https://www.ncbi.nlm.nih.gov/pubmed/36937883
http://dx.doi.org/10.3389/fphar.2023.1150313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020352/
https://www.ncbi.nlm.nih.gov/pubmed/36937883
http://dx.doi.org/10.3389/fphar.2023.1150313

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