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Design and development of novel, short, stable dynorphin-based opioid agonists for safer analgesic therapy
Kappa opioid receptors have exceptional potential as an analgesic target, seemingly devoid of many problematic Mu receptor side-effects. Kappa-selective, small molecule pharmaceutical agents have been developed, but centrally mediated side-effects limit clinical translation. We modify endogenous dyn...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020352/ https://www.ncbi.nlm.nih.gov/pubmed/36937883 http://dx.doi.org/10.3389/fphar.2023.1150313 |