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Mechanism underlying delayed rectifying in human voltage-mediated activation Eag2 channel

The transmembrane voltage gradient is a general physico-chemical cue that regulates diverse biological function through voltage-gated ion channels. How voltage sensing mediates ion flows remains unknown at the molecular level. Here, we report six conformations of the human Eag2 (hEag2) ranging from...

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Detalles Bibliográficos
Autores principales: Zhang, Mingfeng, Shan, Yuanyue, Pei, Duanqing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020445/
https://www.ncbi.nlm.nih.gov/pubmed/36928654
http://dx.doi.org/10.1038/s41467-023-37204-6