Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation

Identifying how small molecules act to kill malaria parasites can lead to new “chemically validated” targets. By pressuring Plasmodium falciparum asexual blood stage parasites with three novel structurally-unrelated antimalarial compounds (MMV665924, MMV019719 and MMV897615), and performing whole-ge...

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Detalles Bibliográficos
Autores principales: Bopp, Selina, Pasaje, Charisse Flerida A., Summers, Robert L., Magistrado-Coxen, Pamela, Schindler, Kyra A., Corpas-Lopez, Victoriano, Yeo, Tomas, Mok, Sachel, Dey, Sumanta, Smick, Sebastian, Nasamu, Armiyaw S., Demas, Allison R., Milne, Rachel, Wiedemar, Natalie, Corey, Victoria, Gomez-Lorenzo, Maria De Gracia, Franco, Virginia, Early, Angela M., Lukens, Amanda K., Milner, Danny, Furtado, Jeremy, Gamo, Francisco-Javier, Winzeler, Elizabeth A., Volkman, Sarah K., Duffey, Maëlle, Laleu, Benoît, Fidock, David A., Wyllie, Susan, Niles, Jacquin C., Wirth, Dyann F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020447/
https://www.ncbi.nlm.nih.gov/pubmed/36927839
http://dx.doi.org/10.1038/s41467-023-36921-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020447/
https://www.ncbi.nlm.nih.gov/pubmed/36927839
http://dx.doi.org/10.1038/s41467-023-36921-2

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