IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation. During late-stage differentiation, osteoclasts become multinucleated and enlarged (so-called “maturation”), suggesting their need to adapt to changin...

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Detalles Bibliográficos
Autores principales: Kim, Hyunsoo, Takegahara, Noriko, Choi, Yongwon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020456/
https://www.ncbi.nlm.nih.gov/pubmed/36928396
http://dx.doi.org/10.1038/s41413-023-00251-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020456/
https://www.ncbi.nlm.nih.gov/pubmed/36928396
http://dx.doi.org/10.1038/s41413-023-00251-2

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