High-capacity adenovector delivery of forced CRISPR-Cas9 heterodimers fosters precise chromosomal deletions in human cells

Genome editing based on dual CRISPR-Cas9 complexes (multiplexes) permits removing specific genomic sequences in living cells leveraging research on functional genomics and genetic therapies. Delivering the required large and multicomponent reagents in a synchronous and stoichiometric manner remains,...

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Detalles Bibliográficos
Autores principales: Tasca, Francesca, Brescia, Marcella, Liu, Jin, Janssen, Josephine M., Mamchaoui, Kamel, Gonçalves, Manuel A.F.V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020486/
https://www.ncbi.nlm.nih.gov/pubmed/36937620
http://dx.doi.org/10.1016/j.omtn.2023.02.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020486/
https://www.ncbi.nlm.nih.gov/pubmed/36937620
http://dx.doi.org/10.1016/j.omtn.2023.02.025

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