Increased IKKϵ protein stability ensures efficient type I interferon responses in conditions of TBK1 deficiency

TBK1 and IKKϵ are related, crucial kinases in antiviral immune signaling pathways downstream of cytosolic nucleic acid receptors such as cGAS and RIG-I-like receptors. Upon activation, they phosphorylate the transcription factors IRF3 and IRF7 and thereby initiate the expression of type I interferon...

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Detalles Bibliográficos
Autores principales: Wegner, Julia, Hunkler, Charlotte, Ciupka, Katrin, Hartmann, Gunther, Schlee, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020501/
https://www.ncbi.nlm.nih.gov/pubmed/36936901
http://dx.doi.org/10.3389/fimmu.2023.1073608

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020501/
https://www.ncbi.nlm.nih.gov/pubmed/36936901
http://dx.doi.org/10.3389/fimmu.2023.1073608

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