Synthesis and structure–activity relationship studies of benzimidazole-thioquinoline derivatives as α-glucosidase inhibitors

In this article, different s-substituted benzimidazole-thioquinoline derivatives were designed, synthesized, and evaluated for their possible α-glucosidase inhibitory activities. The most active compound in this series, 6j (X = 4-bromobenzyl) exhibited significant potency with an IC(50) value of 28....

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Detalles Bibliográficos
Autores principales: Moghadam Farid, Sara, Noori, Milad, Nazari Montazer, Mohammad, Khalili Ghomi, Minoo, Mollazadeh, Marjan, Dastyafteh, Navid, Irajie, Cambyz, Zomorodian, Kamiar, Mirfazli, Seyedeh Sara, Mojtabavi, Somayeh, Faramarzi, Mohammad Ali, Larijani, Bagher, Iraji, Aida, Mahdavi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020548/
https://www.ncbi.nlm.nih.gov/pubmed/36928433
http://dx.doi.org/10.1038/s41598-023-31080-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020548/
https://www.ncbi.nlm.nih.gov/pubmed/36928433
http://dx.doi.org/10.1038/s41598-023-31080-2

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