Mitochondrial Lon-induced mitophagy benefits hypoxic resistance via Ca(2+)-dependent FUNDC1 phosphorylation at the ER-mitochondria interface

During hypoxia, FUNDC1 acts as a mitophagy receptor and accumulates at the ER (endoplasmic reticulum)-mitochondria contact sites (EMC), also called mitochondria-associated membranes (MAM). In mitophagy, the ULK1 complex phosphorylates FUNDC1(S17) at the EMC site. However, how mitochondria sense the...

Descripción completa

Detalles Bibliográficos
Autores principales: Ponneri Babuharisankar, Ananth, Kuo, Cheng-Liang, Chou, Han-Yu, Tangeda, Vidhya, Fan, Chi-Chen, Chen, Chung-Hsing, Kao, Yung-Hsi, Lee, Alan Yueh-Luen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020552/
https://www.ncbi.nlm.nih.gov/pubmed/36927870
http://dx.doi.org/10.1038/s41419-023-05723-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020552/
https://www.ncbi.nlm.nih.gov/pubmed/36927870
http://dx.doi.org/10.1038/s41419-023-05723-1

Ejemplares similares