Integration of molecular modelling and in vitro studies to inhibit LexA proteolysis

INTRODUCTION: As antibiotic resistance has become more prevalent, the social and economic impacts are increasingly pressing. Indeed, bacteria have developed the SOS response which facilitates the evolution of resistance under genotoxic stress. The transcriptional repressor, LexA, plays a key role in...

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Detalles Bibliográficos
Autores principales: Schuurs, Zachariah P., McDonald, John P., Croft, Laura V., Richard, Derek J., Woodgate, Roger, Gandhi, Neha S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020695/
https://www.ncbi.nlm.nih.gov/pubmed/36936756
http://dx.doi.org/10.3389/fcimb.2023.1051602

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10020695/
https://www.ncbi.nlm.nih.gov/pubmed/36936756
http://dx.doi.org/10.3389/fcimb.2023.1051602

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