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Favoring the hierarchical constraint in penalized survival models for randomized trials in precision medicine
BACKGROUND: The research of biomarker-treatment interactions is commonly investigated in randomized clinical trials (RCT) for improving medicine precision. The hierarchical interaction constraint states that an interaction should only be in a model if its main effects are also in the model. However,...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022294/ https://www.ncbi.nlm.nih.gov/pubmed/36927444 http://dx.doi.org/10.1186/s12859-023-05162-x |