Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia

AIMS: Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium channel SCN5A undergoes foetal-to-adult isoform switching around birth. Conventional hiPSC-CM cultures, which are phenotypica...

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Detalles Bibliográficos
Autores principales: Campostrini, Giulia, Kosmidis, Georgios, Ward-van Oostwaard, Dorien, Davis, Richard Paul, Yiangou, Loukia, Ottaviani, Daniele, Veerman, Christiaan Cornelis, Mei, Hailiang, Orlova, Valeria Viktorovna, Wilde, Arthur Arnold Maria, Bezzina, Connie Rose, Verkerk, Arie Otto, Mummery, Christine Lindsay, Bellin, Milena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022870/
https://www.ncbi.nlm.nih.gov/pubmed/35394010
http://dx.doi.org/10.1093/cvr/cvac059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022870/
https://www.ncbi.nlm.nih.gov/pubmed/35394010
http://dx.doi.org/10.1093/cvr/cvac059

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