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Maturation of hiPSC-derived cardiomyocytes promotes adult alternative splicing of SCN5A and reveals changes in sodium current associated with cardiac arrhythmia
AIMS: Human-induced pluripotent stem cell-cardiomyocytes (hiPSC-CMs) are widely used to study arrhythmia-associated mutations in ion channels. Among these, the cardiac sodium channel SCN5A undergoes foetal-to-adult isoform switching around birth. Conventional hiPSC-CM cultures, which are phenotypica...
Autores principales: | Campostrini, Giulia, Kosmidis, Georgios, Ward-van Oostwaard, Dorien, Davis, Richard Paul, Yiangou, Loukia, Ottaviani, Daniele, Veerman, Christiaan Cornelis, Mei, Hailiang, Orlova, Valeria Viktorovna, Wilde, Arthur Arnold Maria, Bezzina, Connie Rose, Verkerk, Arie Otto, Mummery, Christine Lindsay, Bellin, Milena |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022870/ https://www.ncbi.nlm.nih.gov/pubmed/35394010 http://dx.doi.org/10.1093/cvr/cvac059 |
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