Cargando…

Physics-based generative model of curvature sensing peptides; distinguishing sensors from binders

Proteins can specifically bind to curved membranes through curvature-induced hydrophobic lipid packing defects. The chemical diversity among such curvature “sensors” challenges our understanding of how they differ from general membrane “binders” that bind without curvature selectivity. Here, we comb...

Descripción completa

Detalles Bibliográficos
Autores principales: van Hilten, Niek, Methorst, Jeroen, Verwei, Nino, Risselada, Herre Jelger
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10022891/
https://www.ncbi.nlm.nih.gov/pubmed/36930719
http://dx.doi.org/10.1126/sciadv.ade8839