Identification of a weight loss-associated causal eQTL in MTIF3 and the effects of MTIF3 deficiency on human adipocyte function

Genetic variation at the MTIF3 (Mitochondrial Translational Initiation Factor 3) locus has been robustly associated with obesity in humans, but the functional basis behind this association is not known. Here, we applied luciferase reporter assay to map potential functional variants in the haplotype...

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Detalles Bibliográficos
Autores principales: Huang, Mi, Coral, Daniel, Ardalani, Hamidreza, Spegel, Peter, Saadat, Alham, Claussnitzer, Melina, Mulder, Hindrik, Franks, Paul W, Kalamajski, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2023
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023155/
https://www.ncbi.nlm.nih.gov/pubmed/36876906
http://dx.doi.org/10.7554/eLife.84168

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023155/
https://www.ncbi.nlm.nih.gov/pubmed/36876906
http://dx.doi.org/10.7554/eLife.84168

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