A molecular switch modulates assembly and host factor binding of the HIV-1 capsid

The HIV-1 capsid is a fullerene cone made of quasi-equivalent hexamers and pentamers of the viral CA protein. Typically, quasi-equivalent assembly of viral capsid subunits is controlled by a molecular switch. Here, we identify a Thr-Val-Gly-Gly motif that modulates CA hexamer/pentamer switching by f...

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Detalles Bibliográficos
Autores principales: Schirra, Randall T., dos Santos, Nayara F. B., Zadrozny, Kaneil K., Kucharska, Iga, Ganser-Pornillos, Barbie K., Pornillos, Owen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023569/
https://www.ncbi.nlm.nih.gov/pubmed/36759579
http://dx.doi.org/10.1038/s41594-022-00913-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023569/
https://www.ncbi.nlm.nih.gov/pubmed/36759579
http://dx.doi.org/10.1038/s41594-022-00913-5

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