A shape-shifting nuclease unravels structured RNA

RNA turnover pathways ensure appropriate gene expression levels by eliminating unwanted transcripts. Dis3-like 2 (Dis3L2) is a 3′–5′ exoribonuclease that plays a critical role in human development. Dis3L2 independently degrades structured substrates, including coding and noncoding 3′ uridylated RNAs...

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Detalles Bibliográficos
Autores principales: Meze, Katarina, Axhemi, Armend, Thomas, Dennis R., Doymaz, Ahmet, Joshua-Tor, Leemor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023572/
https://www.ncbi.nlm.nih.gov/pubmed/36823385
http://dx.doi.org/10.1038/s41594-023-00923-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023572/
https://www.ncbi.nlm.nih.gov/pubmed/36823385
http://dx.doi.org/10.1038/s41594-023-00923-x

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