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A shape-shifting nuclease unravels structured RNA

RNA turnover pathways ensure appropriate gene expression levels by eliminating unwanted transcripts. Dis3-like 2 (Dis3L2) is a 3′–5′ exoribonuclease that plays a critical role in human development. Dis3L2 independently degrades structured substrates, including coding and noncoding 3′ uridylated RNAs...

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Detalles Bibliográficos
Autores principales:	Meze, Katarina, Axhemi, Armend, Thomas, Dennis R., Doymaz, Ahmet, Joshua-Tor, Leemor
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group US 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023572/ https://www.ncbi.nlm.nih.gov/pubmed/36823385 http://dx.doi.org/10.1038/s41594-023-00923-x

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