Direct visualization of transcription-replication conflicts reveals post-replicative DNA:RNA hybrids

Transcription-replication collisions (TRCs) are crucial determinants of genome instability. R-loops were linked to head-on TRCs and proposed to obstruct replication fork progression. The underlying mechanisms, however, remained elusive due to the lack of direct visualization and of non-ambiguous res...

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Detalles Bibliográficos
Autores principales: Stoy, Henriette, Zwicky, Katharina, Kuster, Danina, Lang, Kevin S, Krietsch, Jana, Crossley, Magdalena P., Schmid, Jonas A., Cimprich, Karlene A., Merrikh, Houra, Lopes, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023573/
https://www.ncbi.nlm.nih.gov/pubmed/36864174
http://dx.doi.org/10.1038/s41594-023-00928-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023573/
https://www.ncbi.nlm.nih.gov/pubmed/36864174
http://dx.doi.org/10.1038/s41594-023-00928-6

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