Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43

Aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43-related neurodegeneration involves multiple changes to normal physiological TDP-43, which undergoes nuclear depletion, cytoplasmic mislocalisation, post-trans...

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Detalles Bibliográficos
Autores principales: Keating, Sean S., Bademosi, Adekunle T., San Gil, Rebecca, Walker, Adam K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023653/
https://www.ncbi.nlm.nih.gov/pubmed/36930291
http://dx.doi.org/10.1007/s00018-023-04739-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023653/
https://www.ncbi.nlm.nih.gov/pubmed/36930291
http://dx.doi.org/10.1007/s00018-023-04739-2

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