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Aggregation-prone TDP-43 sequesters and drives pathological transitions of free nuclear TDP-43
Aggregation of the RNA-binding protein, TDP-43, is the unifying hallmark of amyotrophic lateral sclerosis and frontotemporal dementia. TDP-43-related neurodegeneration involves multiple changes to normal physiological TDP-43, which undergoes nuclear depletion, cytoplasmic mislocalisation, post-trans...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023653/ https://www.ncbi.nlm.nih.gov/pubmed/36930291 http://dx.doi.org/10.1007/s00018-023-04739-2 |