Targeting Ras-binding domain of ELMO1 by computational nanobody design

The control of cell movement through manipulation of cytoskeletal structure has therapeutic prospects notably in the development of novel anti-metastatic drugs. In this study, we determine the structure of Ras-binding domain (RBD) of ELMO1, a protein involved in cytoskeletal regulation, both alone a...

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Detalles Bibliográficos
Autores principales: Tam, Chunlai, Kukimoto-Niino, Mutsuko, Miyata-Yabuki, Yukako, Tsuda, Kengo, Mishima-Tsumagari, Chiemi, Ihara, Kentaro, Inoue, Mio, Yonemochi, Mayumi, Hanada, Kazuharu, Matsumoto, Takehisa, Shirouzu, Mikako, Zhang, Kam Y. J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023680/
https://www.ncbi.nlm.nih.gov/pubmed/36932164
http://dx.doi.org/10.1038/s42003-023-04657-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023680/
https://www.ncbi.nlm.nih.gov/pubmed/36932164
http://dx.doi.org/10.1038/s42003-023-04657-w

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