Proximity proteomics identifies septins and PAK2 as decisive regulators of actomyosin-mediated expulsion of von Willebrand factor

In response to tissue injury, within seconds the ultra-large glycoprotein von Willebrand factor (VWF) is released from endothelial storage organelles (Weibel−Palade bodies) into the lumen of the blood vasculature, where it leads to the recruitment of platelets. The marked size of VWF multimers repre...

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Detalles Bibliográficos
Autores principales: El-Mansi, Sammy, Robinson, Christopher L., Kostelnik, Katja B., McCormack, Jessica J., Mitchell, Tom P., Lobato-Márquez, Damián, Rajeeve, Vinothini, Cutillas, Pedro, Cutler, Daniel F., Mostowy, Serge, Nightingale, Thomas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2023
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023740/
https://www.ncbi.nlm.nih.gov/pubmed/36564030
http://dx.doi.org/10.1182/blood.2022017419

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023740/
https://www.ncbi.nlm.nih.gov/pubmed/36564030
http://dx.doi.org/10.1182/blood.2022017419

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