Engineering olivocochlear inhibition to reduce acoustic trauma

Efferent brain-stem neurons release acetylcholine to desensitize cochlear hair cells and can protect the inner ear from acoustic trauma. That protection is absent from knockout mice lacking efferent inhibition and is stronger in mice with a gain-of-function point mutation of the hair cell-specific n...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Yuanyuan, Hiel, Hakim, Vincent, Philippe F.Y., Wood, Megan B., Elgoyhen, Ana B., Chien, Wade, Lauer, Amanda, Fuchs, Paul A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023855/
https://www.ncbi.nlm.nih.gov/pubmed/36941920
http://dx.doi.org/10.1016/j.omtm.2023.02.011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10023855/
https://www.ncbi.nlm.nih.gov/pubmed/36941920
http://dx.doi.org/10.1016/j.omtm.2023.02.011

Ejemplares similares