Combination of epigenetic erasing and mechanical cues to generate human epiBlastoids from adult dermal fibroblasts

PURPOSE: This study is to develop a new protocol that combines the use of epigenetic cues and mechanical stimuli to assemble 3D spherical structures, arbitrarily defined “epiBlastoids,” whose phenotype is remarkably similar to natural embryos. METHODS: A 3-step approach is used to generate epiBlasto...

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Detalles Bibliográficos
Autores principales: Pennarossa, Georgia, Arcuri, Sharon, De Iorio, Teresina, Ledda, Sergio, Gandolfi, Fulvio, Brevini, Tiziana A. L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Technological Innovations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024007/
https://www.ncbi.nlm.nih.gov/pubmed/36933093
http://dx.doi.org/10.1007/s10815-023-02773-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024007/
https://www.ncbi.nlm.nih.gov/pubmed/36933093
http://dx.doi.org/10.1007/s10815-023-02773-4

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