A new electrochemical method that mimics phosphorylation of the core tau peptide K18 enables kinetic and structural analysis of intermediates and assembly

Tau protein’s reversible assembly and binding of microtubules in brain neurons are regulated by charge-neutralizing phosphorylation, while its hyperphosphorylation drives the irreversible formation of cytotoxic filaments associated with neurodegenerative diseases. However, the structural changes tha...

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Detalles Bibliográficos
Autores principales: Masquelier, Eloise, Taxon, Esther, Liang, Sheng-Ping, Al Sabeh, Yahya, Sepunaru, Lior, Gordon, Michael J., Morse, Daniel E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024187/
https://www.ncbi.nlm.nih.gov/pubmed/36781124
http://dx.doi.org/10.1016/j.jbc.2023.103011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024187/
https://www.ncbi.nlm.nih.gov/pubmed/36781124
http://dx.doi.org/10.1016/j.jbc.2023.103011

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