Synthesis and Biological Evaluation of Novel Anti-leukemia Proteolysis-Targeting Chimeras in Degradating Inosine Monophosphate Dehydrogenase

BACKGROUND: Proteolysis-targeting chimera (PROTAC) is a bifunctional molecule comprising a ligand to recognize the targeted protein to be degraded. OBJECTIVES: To use the advantages of the PROTAC technique, we have synthesized novel compounds to degrade inosine monophosphate dehydrogenase (IMPDH) by...

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Detalles Bibliográficos
Autores principales: Sohbati, Hamidreza, Amini, Mohsen, Balalaie, Saeed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Brieflands 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024327/
https://www.ncbi.nlm.nih.gov/pubmed/36942064
http://dx.doi.org/10.5812/ijpr-129251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024327/
https://www.ncbi.nlm.nih.gov/pubmed/36942064
http://dx.doi.org/10.5812/ijpr-129251

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