Loss of Kmt2c in vivo leads to EMT, mitochondrial dysfunction and improved response to lapatinib in breast cancer

Deep sequencing of human tumours has uncovered a previously unappreciated role for epigenetic regulators in tumorigenesis. H3K4 methyltransferase KMT2C/MLL3 is mutated in several solid malignancies, including more than 10% of breast tumours. To study the tumour suppressor role of KMT2C in breast can...

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Detalles Bibliográficos
Autores principales: Simigdala, Nikiana, Chalari, Anna, Sklirou, Aimilia D., Chavdoula, Evangelia, Papafotiou, George, Melissa, Pelagia, Kafalidou, Aimilia, Paschalidis, Nikolaos, Pateras, Ioannis S., Athanasiadis, Emmanouil, Konstantopoulos, Dimitris, Trougakos, Ioannis P., Klinakis, Apostolos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024673/
https://www.ncbi.nlm.nih.gov/pubmed/36933062
http://dx.doi.org/10.1007/s00018-023-04734-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024673/
https://www.ncbi.nlm.nih.gov/pubmed/36933062
http://dx.doi.org/10.1007/s00018-023-04734-7

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