PIK3CA and PIK3R1 tumor mutational landscape in a pan-cancer patient cohort and its association with pathway activation and treatment efficacy

There is little data concerning the implications of PIK3CA mutations outside of the known hotspots described in ER+/HER2− metastatic breast cancer (mBC). Similarly, PIK3R1 mutations could also lead to activation of PI3K pathway, but are poorly described. We determined the incidence and type of all s...

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Detalles Bibliográficos
Autores principales: Tharin, Zoé, Richard, Corentin, Derangère, Valentin, Ilie, Alis, Arnould, Laurent, Ghiringhelli, François, Boidot, Romain, Ladoire, Sylvain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024711/
https://www.ncbi.nlm.nih.gov/pubmed/36934165
http://dx.doi.org/10.1038/s41598-023-31593-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024711/
https://www.ncbi.nlm.nih.gov/pubmed/36934165
http://dx.doi.org/10.1038/s41598-023-31593-w

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