CRISPR-Cas9 editing of TLR4 to improve the outcome of cardiac cell therapy

Inflammation and fibrosis limit the reparative properties of human mesenchymal stromal cells (hMSCs). We hypothesized that disrupting the toll-like receptor 4 (TLR4) gene would switch hMSCs toward a reparative phenotype and improve the outcome of cell therapy for infarct repair. We developed and opt...

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Detalles Bibliográficos
Autores principales: Schary, Yeshai, Rotem, Itai, Caller, Tal, Lewis, Nir, Shaihov-Teper, Olga, Brzezinski, Rafael Y., Lendengolts, Daria, Raanani, Ehud, Sternik, Leonid, Naftali-Shani, Nili, Leor, Jonathan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024743/
https://www.ncbi.nlm.nih.gov/pubmed/36934130
http://dx.doi.org/10.1038/s41598-023-31286-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024743/
https://www.ncbi.nlm.nih.gov/pubmed/36934130
http://dx.doi.org/10.1038/s41598-023-31286-4

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