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CRISPR-Cas9 editing of TLR4 to improve the outcome of cardiac cell therapy
Inflammation and fibrosis limit the reparative properties of human mesenchymal stromal cells (hMSCs). We hypothesized that disrupting the toll-like receptor 4 (TLR4) gene would switch hMSCs toward a reparative phenotype and improve the outcome of cell therapy for infarct repair. We developed and opt...
Autores principales: | Schary, Yeshai, Rotem, Itai, Caller, Tal, Lewis, Nir, Shaihov-Teper, Olga, Brzezinski, Rafael Y., Lendengolts, Daria, Raanani, Ehud, Sternik, Leonid, Naftali-Shani, Nili, Leor, Jonathan |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10024743/ https://www.ncbi.nlm.nih.gov/pubmed/36934130 http://dx.doi.org/10.1038/s41598-023-31286-4 |
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