New flavone-based arylamides as potential V600E-BRAF inhibitors: Molecular docking, DFT, and pharmacokinetic properties

OBJECTIVES: The V600E-BRAF protein kinase is an attractive and essential therapeutic target in melanoma and other tumors. However, because of its resistance to the known inhibitors and side effects of some identified inhibitors, new potent inhibitors need to be identified. METHODS: In the present wo...

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Detalles Bibliográficos
Autores principales: Umar, Abdullahi B., Uzairu, Adamu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taibah University 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025095/
https://www.ncbi.nlm.nih.gov/pubmed/36950455
http://dx.doi.org/10.1016/j.jtumed.2023.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10025095/
https://www.ncbi.nlm.nih.gov/pubmed/36950455
http://dx.doi.org/10.1016/j.jtumed.2023.02.010

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